ANTIBACTERIAL ACTIVITY OF NEW β-LACTAM COMPOUND

A new β-lactam molecule A1 was synthesized and formulated to introduce an innovative solution in order to circumvent the bacterial resistance and their defenses against antibiotics. This innovative molecule was tested towards representative Gram positive and Gram negative strains of antibiotic-resistant pathogenic bacteria to evaluate its antibacterial activity and to analyze the action spectrum and the antibacterial effectiveness. Results showed that the new compound A1 was synthesized with a yield of 55% and demonstrated the antimicrobial activity against all tested bacteria, except Pseudomonas aeruginosa, and all Gram-positive bacteria were more sensitive with a good antimicrobial activity. Moreover, as the determined MIC90, both strains of the Streptococcus genus were inhibited at a concentration of 16 μg/ml of the compound A1, while Staphylococcus aureus resulted sensitive to an inhibitory concentration of 64 μg/ml. The Gram-negative bacteria, instead, required an inhibitory concentration of 64 μg/ml for Escherichia coli and 128 μg/ml for Klebsiella pneumoniae. In conclusion, compound A1 is a promising molecule to develop a new class of safe and active antibiotics, with a predicted good inhibitory capacity not only against Gram positive, but also Gram negative microorganisms. Keywords: β-lactam compound