Early Fire Detection with Higher Sensitivity and Timeliness: Porting the RST-FIRES Algorithm to Rapid Scan Geostationary Data

In this work, the portability of the Robust Satellite Techniques for FIRES detection and monitoring (RST-FIRES) has been preliminary experimented on the Spinning Enhanced Visible and InfraRed Imager (SEVIRI) aboard the Meteosat Second Generation (MSG) satellite in Rapid Scan Service (RSS) mode. Such a configuration offers 5 min of revisit time as compared with 15 min in the standard mode (0-degree). The impact in early fire detec-tion has been assessed and quantified, also in comparison with ...

Deregulated expression and activity of Farnesyl Diphosphate Synthase (FDPS) in Glioblastoma

Glioblastoma (GBM), the most aggressive brain cancer, is highly dependent on the mevalonate (MVA) pathway for the synthesis of lipid moieties critical for cell proliferation but the function and regulation of key intermediate enzymes like farnesyl-diphosphate synthase (FDPS), up to now, remained unknown. A deregulated expression and activity of FDPS was the central research idea of the present study. FDPS mRNA, protein and enzyme activity were analyzed in a cohort of stage III-IV glioma patie...

Cannabinoid receptor CB1 regulates STAT3 activity and its expression dictates the responsiveness to SR141716 treatment in human glioma patients’ cells

Herein we show that a majority of human brain tumor samples and cell lines over-expressed cannabinoid receptor CB1 as compared to normal human astrocytes (NHA), while uniformly expressed low levels of CB2. This finding prompted us to investigate the therapeutic exploitation of CB1 inactivation by SR141716 treatment, with regard to its direct and indirect cell-mediated effects against gliomas. Functional studies, using U251MG glioma cells and primary tumor cell lines derived from glioma patien...

N6-isopentenyladenosine affects cytotoxic activity and cytokines production by IL-2 activated NK cells and exerts topical anti-inflammatory activity in mice