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Sex-based immunological differences in multisystem inflammatory syndrome in children: potential role of TR3–56 cells for pathogenesis, diagnosis, and therapy

Multisystem Inflammatory Syndrome in Children (MIS-C) is characterized by immune dysregulation, exhibiting clinical and immunological features reminiscent of autoimmune processes, although its underlying mechanisms remain incompletely understood. This study examines immune system alterations in MIS-C patients, focusing on TR3–56 lymphocytes, a novel population of regulatory T cells. Our findings reveal a positive correlation between circulating TR3–56 cells and regulatory T cells, suggesting ...

Nuclear analyses in support of the water-cooled lithium lead breeding blanket design development: a prospective strategy to achieve the tritium self-sufficiency

The development of a closed tritium fuel cycle is essential for the sustainable operation of future fusion power plants. Within the EUROfusion roadmap, the Water-Cooled Lithium Lead (WCLL) breeding blanket is a key candidate for the Demonstration Fusion Power Reactor (DEMO). It uses pressurized water as coolant and a liquid lithium-lead (LiPb) eutectic alloy as both breeder and neutron multiplier. The current WCLL design features modular inboard and outboard Breeding Units (BUs) composed of h...

Advancements of testing activities for development of in-bore welding tool for large feeding pipes of in-vessel components

This work presents the results of welding tests made on large pipes (DN200) in austenitic stainless steel AISI316L to be used in the nuclear fusion DEMOnstration power plant, DEMO. Samples were designed and manufactured to physically simulate the coupling and the alignment of the two pipes and their joining by an in-bore welding system. The trajectories describing the movement of the TIG torch during the operation were selected for the specific geometric configuration where the multi-pass ope...

Nitti e gli interventi speciali per il Mezzogiorno del 1904. Per una comparazione tra il caso napoletano e quello lucano.

L’articolo propone una lettura comparata dei due interventi straordinari per il Mezzogiorno promossi da Zanardelli e Giolitti, ovvero quello per la Basilicata (l. 140/1904) e quello per Napoli (l. 351/1904). I “laboratori speciali” che ne sarebbero seguiti avrebbero avuto in Francesco Saverio Nitti uno dei protagonisti principali: estensore di fatto del progetto industrialista per Napoli, si sarebbe espresso con toni molto critici nei confronti del tradizionale impianto di quello varato per l...

Serum miRNAs as biomarkers in Neurofibromatosis 1: New promising findings

Objective: Neurofibromatosis type 1 (NF1) is a neurocutaneous genetic disorder caused by dominant mutations in the NF1 gene and characterized by increased susceptibility to develop benign and malignant tumors. The type of NF1 mutation, the expression of gene modifiers as well as epigenetic factors correlate with the clinical heterogeneity. In this regard microRNAs (miRNAs) play a role in post-transcriptional gene regulation. Compelling evidence shows that circulating miRNAs mirror pathophysio...

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Prodotti recenti

Sex-based immunological differences in multisystem inflammatory syndrome in children: potential role of TR3–56 cells for pathogenesis, diagnosis, and therapy

Nuclear analyses in support of the water-cooled lithium lead breeding blanket design development: a prospective strategy to achieve the tritium self-sufficiency

Advancements of testing activities for development of in-bore welding tool for large feeding pipes of in-vessel components

Nitti e gli interventi speciali per il Mezzogiorno del 1904. Per una comparazione tra il caso napoletano e quello lucano.

Serum miRNAs as biomarkers in Neurofibromatosis 1: New promising findings

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