Cytarabine, the 4-Amino-1-(β-D-arabinofuranosyl)-2(1H)-pyrimidinone, (ARA-C), is an antimetabolite cytidine analogue used worldwide as key drug in the management of leukaemia. As specified in the manufacturers’ instructions, once the components – sterile water and ARA-C powder – are unpackaged and mixed, the solution begins to degrade after 6 hours at room temperature and 12 hours at 4 °C

AN HPLC AND 1H NMR STUDY OF THE CYTARABINE DEGRADATION IN CLINICAL CONDITIONS TO AVOID DRUG WASTE, DECREASE THERAPY COSTS AND IMPROVE PATIENT COMPLIANCE

MANFRA, MICHELE;
2016-01-01

Abstract

Cytarabine, the 4-Amino-1-(β-D-arabinofuranosyl)-2(1H)-pyrimidinone, (ARA-C), is an antimetabolite cytidine analogue used worldwide as key drug in the management of leukaemia. As specified in the manufacturers’ instructions, once the components – sterile water and ARA-C powder – are unpackaged and mixed, the solution begins to degrade after 6 hours at room temperature and 12 hours at 4 °C
2016
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11563/122221
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