The inter-molecular carbolithiation of unfunctionalized and functionalized alkenes, followed by electrophile trapping, provides a versatile and useful tool for the construction of complex molecular systems, allowing the simultaneous creation of up to two novel carbon-carbon or carbon-heteroatom bonds. In this review a full overview oninter-molecular carbolithiation processes is reported, with a main focus on the chemo-, regio- and stereo-control of the reaction and on the strategies for asymmetric processes.
Regio- And stereoselective intermolecular carbolithiation reactions
Marsico G.;Scafato P.;Belviso S.;Superchi S.
2020-01-01
Abstract
The inter-molecular carbolithiation of unfunctionalized and functionalized alkenes, followed by electrophile trapping, provides a versatile and useful tool for the construction of complex molecular systems, allowing the simultaneous creation of up to two novel carbon-carbon or carbon-heteroatom bonds. In this review a full overview oninter-molecular carbolithiation processes is reported, with a main focus on the chemo-, regio- and stereo-control of the reaction and on the strategies for asymmetric processes.File in questo prodotto:
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