Cytarabine (4-Amino-1-(β-D-arabinofuranosyl)-2(1H)- pyrimidinone, Ara-C) a deoxycytidine analogue, is one of the most active drugs in the treatment of acute leukemias and is widely applied at a variety of other hematological malignancies. Although chemical and physical in-use stability of commercial Ara-C has been recommended for 48 hours at room temperature after dilution, from a microbiological point of view (data from drug informative sheet of Aracytin, available in Italy), the product should be used immediately. The cancer drugs preparation and dispensing in designated centralized chemotherapy (CHT) preparation pharmacy units (CPU) has been extensively studied to improve its quality and minimize personnel exposure to these drugs. We know relative little about the possibility to optimize and economize the use of CHT agents in CPU.Here we explore the chemical and microbiological stability of a commercial Ara-C sample (Aracytin) in its pharmaceutical form after its reconstitution and storage at 4°C, in order to save drug

SAVING MONEY AND COMFORT BY GAINING CYTOSINE ARABINOSIDE MICROGRAMS

MANFRA, MICHELE;
2014-01-01

Abstract

Cytarabine (4-Amino-1-(β-D-arabinofuranosyl)-2(1H)- pyrimidinone, Ara-C) a deoxycytidine analogue, is one of the most active drugs in the treatment of acute leukemias and is widely applied at a variety of other hematological malignancies. Although chemical and physical in-use stability of commercial Ara-C has been recommended for 48 hours at room temperature after dilution, from a microbiological point of view (data from drug informative sheet of Aracytin, available in Italy), the product should be used immediately. The cancer drugs preparation and dispensing in designated centralized chemotherapy (CHT) preparation pharmacy units (CPU) has been extensively studied to improve its quality and minimize personnel exposure to these drugs. We know relative little about the possibility to optimize and economize the use of CHT agents in CPU.Here we explore the chemical and microbiological stability of a commercial Ara-C sample (Aracytin) in its pharmaceutical form after its reconstitution and storage at 4°C, in order to save drug
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11563/96295
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