A glucose biosensor, based on glucose oxidase immobilized in a non-conducting (overoxidised) polypyrrole film, is described which proved practically immune from faradaic interference arising from endogeneous (ascorbate, urate, cysteine) and exogeneous (acetaminophen) electroactive interferents. The bias introduced in the measurement of 5 mM glucose by the given interferents at their maximum physiological levels never exceeded 2% which is, by far, the lowest value ever reported. The biosensor has been used for continuous subcutaneous monitoring of glucose in a rabbit implanted with a microdialysis probe. The potential and limits of this approach are discussed.
An interference-free biosensor based on glucose oxidase electrochemically immobilized in a non-conducting poly(pyrrole) film for continuous subcutaneous monitoring of glucose through microdialysis sampling
GUERRIERI, Antonio;
1993-01-01
Abstract
A glucose biosensor, based on glucose oxidase immobilized in a non-conducting (overoxidised) polypyrrole film, is described which proved practically immune from faradaic interference arising from endogeneous (ascorbate, urate, cysteine) and exogeneous (acetaminophen) electroactive interferents. The bias introduced in the measurement of 5 mM glucose by the given interferents at their maximum physiological levels never exceeded 2% which is, by far, the lowest value ever reported. The biosensor has been used for continuous subcutaneous monitoring of glucose in a rabbit implanted with a microdialysis probe. The potential and limits of this approach are discussed.File | Dimensione | Formato | |
---|---|---|---|
Binder1.pdf
accesso aperto
Tipologia:
Documento in Post-print
Licenza:
DRM non definito
Dimensione
171.87 kB
Formato
Adobe PDF
|
171.87 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.