Two new biflavonoids, 2″-hydroxygenkwanol A (1) and 4′-methylgenkwanol A (2), together with fourteen known compounds were isolated from the aerial parts of Daphne linearifolia Hart. Their chemical structures were elucidated by extensive NMR spectral studies, as well as by ESI-MS analysis. The affinity of all compounds towards Hsp90, one of the most promising targets for the modern anti-cancer therapy, by surface plasmon resonance was tested. Achieved results demonstrated that 1 efficiently interacts with the protein, also allowing some structure-activity relationship evaluations.

Biflavonoids from Daphne linearifolia Hart.

VASSALLO, ANTONIO;
2012-01-01

Abstract

Two new biflavonoids, 2″-hydroxygenkwanol A (1) and 4′-methylgenkwanol A (2), together with fourteen known compounds were isolated from the aerial parts of Daphne linearifolia Hart. Their chemical structures were elucidated by extensive NMR spectral studies, as well as by ESI-MS analysis. The affinity of all compounds towards Hsp90, one of the most promising targets for the modern anti-cancer therapy, by surface plasmon resonance was tested. Achieved results demonstrated that 1 efficiently interacts with the protein, also allowing some structure-activity relationship evaluations.
2012
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11563/31631
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