Two new biflavonoids, 2″-hydroxygenkwanol A (1) and 4′-methylgenkwanol A (2), together with fourteen known compounds were isolated from the aerial parts of Daphne linearifolia Hart. Their chemical structures were elucidated by extensive NMR spectral studies, as well as by ESI-MS analysis. The affinity of all compounds towards Hsp90, one of the most promising targets for the modern anti-cancer therapy, by surface plasmon resonance was tested. Achieved results demonstrated that 1 efficiently interacts with the protein, also allowing some structure-activity relationship evaluations.
Biflavonoids from Daphne linearifolia Hart.
VASSALLO, ANTONIO;
2012-01-01
Abstract
Two new biflavonoids, 2″-hydroxygenkwanol A (1) and 4′-methylgenkwanol A (2), together with fourteen known compounds were isolated from the aerial parts of Daphne linearifolia Hart. Their chemical structures were elucidated by extensive NMR spectral studies, as well as by ESI-MS analysis. The affinity of all compounds towards Hsp90, one of the most promising targets for the modern anti-cancer therapy, by surface plasmon resonance was tested. Achieved results demonstrated that 1 efficiently interacts with the protein, also allowing some structure-activity relationship evaluations.File in questo prodotto:
File | Dimensione | Formato | |
---|---|---|---|
Malafronte et al. - Phytochemistry Letters 2012.pdf
non disponibili
Descrizione: Articolo principale
Tipologia:
Pdf editoriale
Licenza:
DRM non definito
Dimensione
487.59 kB
Formato
Adobe PDF
|
487.59 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.