A simple high-yield three-steps route to optically active 4-hydroxymethyl-3-(1Hindolyl) oxazolidin-2-ones from (S)-glycidol is described. The key intermediates (R)-oxiran-2- ylmethyl 1H-indol-4/-5-ylcarbamates are obtained in high yields from (S)-glycidol. These are readily transformed to oxazolidin-2-ones, very interesting building blocks in drug synthesis.
Stereoselective Intramolecular Cyclization to 4-(Hydroxymethyl)-3-(1H-indolyl)oxazolidin-2-ones
CHIUMMIENTO, Lucia;FUNICELLO, Maria;
2012-01-01
Abstract
A simple high-yield three-steps route to optically active 4-hydroxymethyl-3-(1Hindolyl) oxazolidin-2-ones from (S)-glycidol is described. The key intermediates (R)-oxiran-2- ylmethyl 1H-indol-4/-5-ylcarbamates are obtained in high yields from (S)-glycidol. These are readily transformed to oxazolidin-2-ones, very interesting building blocks in drug synthesis.File in questo prodotto:
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