A mild, efficient, eco-friendly method for the regioselective halogenation of arylboronic acids in water has been reported. A transition-metal-free ipso-chlorination of arylboronic acids was performed in water, yielding aryl chlorides. Ipso-brominated and iodinated compounds were obtained under the same conditions using the corresponding halide salts. This eco-friendly method operates efficiently, even on activated or nonactivated systems, with good yields and selectivity.
NCS-Mediated Ipso-Halogenation of Arylboronic Acids in Water Using Sodium Halides
Alessandro Santarsiere
;Pierantonio Galgano;Maria Funicello;Paolo Lupattelli;Lucia Chiummiento
2025-01-01
Abstract
A mild, efficient, eco-friendly method for the regioselective halogenation of arylboronic acids in water has been reported. A transition-metal-free ipso-chlorination of arylboronic acids was performed in water, yielding aryl chlorides. Ipso-brominated and iodinated compounds were obtained under the same conditions using the corresponding halide salts. This eco-friendly method operates efficiently, even on activated or nonactivated systems, with good yields and selectivity.File in questo prodotto:
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