Three new oleanane saponins (1-3), together with four known ones (4-7), were isolated from the aerial parts of Polyscias guilfoylei. Their structures were elucidated by 1D and 2D NMR experiments, including I D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human cancer cell lines; J774.A1, HEK-293, and WEHI-164. All the compounds were inactive except for 3 beta-O-[beta-D-glucopyranosyl-(1 -> 2)-alpha-L-arabinopyranosyl]-echinocystic acid 28-[O-beta-D-glucopyranosyl-(1 -> 6)O-beta-D-glucopyranosyl] ester (3), which was active against all the cell lines.
Antiproliferative oleanane saponins from Polyscias guilfoylei.
VASSALLO, ANTONIO;
2008-01-01
Abstract
Three new oleanane saponins (1-3), together with four known ones (4-7), were isolated from the aerial parts of Polyscias guilfoylei. Their structures were elucidated by 1D and 2D NMR experiments, including I D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human cancer cell lines; J774.A1, HEK-293, and WEHI-164. All the compounds were inactive except for 3 beta-O-[beta-D-glucopyranosyl-(1 -> 2)-alpha-L-arabinopyranosyl]-echinocystic acid 28-[O-beta-D-glucopyranosyl-(1 -> 6)O-beta-D-glucopyranosyl] ester (3), which was active against all the cell lines.| File | Dimensione | Formato | |
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Cioffi et al. - Natural Product Communications 2008.pdf
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