BAG3 protein has emerged as a key regulator of important cellular processes and its expression is increased in some tumor types; however, despite its potential value for future chemotherapeutics, no selective BAG3 modulators have been yet reported. Here we report the 2,4-thiazolidinedione derivative 28 as the first BAG3 protein modulator.
Discovery and synthesis of the first selective BAG domain modulator of BAG3 as an attractive candidate for the development of a new class of chemotherapeutics
Antonio Vassallo;
2018-01-01
Abstract
BAG3 protein has emerged as a key regulator of important cellular processes and its expression is increased in some tumor types; however, despite its potential value for future chemotherapeutics, no selective BAG3 modulators have been yet reported. Here we report the 2,4-thiazolidinedione derivative 28 as the first BAG3 protein modulator.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
Teracciano et al 2018 - Chem Comm.pdf
solo utenti autorizzati
Descrizione: Articolo principale
Tipologia:
Pdf editoriale
Licenza:
DRM non definito
Dimensione
1.7 MB
Formato
Adobe PDF
|
1.7 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
|
Terracciano et al 2018 - Chemcomm - Supporting Information.pdf
solo utenti autorizzati
Descrizione: Supporting Information
Tipologia:
Pdf editoriale
Licenza:
DRM non definito
Dimensione
285.94 kB
Formato
Adobe PDF
|
285.94 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
