Biopolymeric self-assembled nanoparticles for enhanced antibacterial activity of Ag-based compounds

Microbial infections are still one of the major causes of death among world population. For this reason, there is an urgent need of new antimicrobial agents that express antibacterial activity. Silver-based compounds are known to be toxic against bacteria. One of the most representative examples is silver sulfadiazine. In our article we report the antibacterial activity of silver Nheterocyclic carbene complexes, tested againt a wide spectrum of microorganisms. MIC and MBC were calculated for each compound. We have also produced a dextran oleate conjugate, that was employed for the preparation of self-assembled biopolymeric nanoparticles.