Influence of the architecture on the molecular mobility of synthetic fragments inspired from human tropoelastin

This work deals with the vibrational, thermal and dielectric characterization of a synthetic peptide (S4) released during the proteolysis of human tropoelastin. This peptide was shown to form amyloid-like fibers implied in neurodegenerative pathologies. The comparison between the linear peptides and the associated amyloid-like fibers evidences the strong influence of the secondary structures on the physical structure and chain dynamics of these polypeptides.