Hsp90 C-terminal ligands are potential new anti-cancer drugs alternative to the more studied N-terminal inhibitors. Here we report the identification of a new dihydropyrimidinone binding the C-terminus, which is not structurally related to other well-known natural and natureinspired inhibitors of this second druggable Hsp90 site.
Targeting the Hsp90 C-terminal domain by the chemically accessible dihydropyrimidinone scaffold
VASSALLO, ANTONIO;
2015-01-01
Abstract
Hsp90 C-terminal ligands are potential new anti-cancer drugs alternative to the more studied N-terminal inhibitors. Here we report the identification of a new dihydropyrimidinone binding the C-terminus, which is not structurally related to other well-known natural and natureinspired inhibitors of this second druggable Hsp90 site.File in questo prodotto:
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Strocchia et al. - Chem Commun 2015.pdf
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Supporting information for Targeting the Hsp90 C-terminal domain by the chemically accessible dihydropyrimidinone scaffold.pdf
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