The role of nutrition in multiple sclerosis (MS) is still unclear and MS therapy is not associated to a particular diet. In this review we show the molecular basis by which dietary factors and life style may exacerbate or ameliorate MS symptoms, by controlling both the metabolic and inflammatory pathways in the cell and the composition of gut microbiota. A persistent “Western style” diet may indeed lead to a dysbiotic gut microbiota, alteration of intestinal immunity and systemic inflammation. On these grounds, there are now good prospects for improving the well being of MS patients on the basis of nutritional intervention and healthy life style.
The role of nutrition in multiple sclerosis: a story yet to be written.
RICCIO, Paolo;ROSSANO, Rocco
2013-01-01
Abstract
The role of nutrition in multiple sclerosis (MS) is still unclear and MS therapy is not associated to a particular diet. In this review we show the molecular basis by which dietary factors and life style may exacerbate or ameliorate MS symptoms, by controlling both the metabolic and inflammatory pathways in the cell and the composition of gut microbiota. A persistent “Western style” diet may indeed lead to a dysbiotic gut microbiota, alteration of intestinal immunity and systemic inflammation. On these grounds, there are now good prospects for improving the well being of MS patients on the basis of nutritional intervention and healthy life style.File | Dimensione | Formato | |
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